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http://hdl.handle.net/10401/1491
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| Título: | A flexible-dose study of Paliperidone ER in non-acute patients with schizophrenia previously unsuccessfully treated with other oral antipsychotics. |
| Autor: | Schreiner, A.
Hoeben, D.
Lahaye, M.
Tessier, C.
Peuskens, J.
Nardini, F.
Albrecht, W.
Jakovljevic, M.
Djukic-Dejanovic, S. |
| Fecha: | jun-2010 |
| Tipo de documento: | Comunicación congreso |
| Resumen: | ● Among patients transitioned to paliperidone ER for the main reason of lack of efficacy with their previous oral antipsychotic, 61% had an improvement in PANSS total scores of ≥ 20% from baseline to endpoint.
● Among patients switching to paliperidone ER for main reasons other than lack of efficacy, PANSS total score at endpoint was not inferior to PANSS total score at
baseline. Even more, PANSS total score from baseline to endpoint improved significantly (P < 0.0001).
● Clinically relevant and statistically significant improvements were observed for PANSS total, PANSS subscale, and Marder factor scores (P < 0.0001).
● The percentage of patients in CGI-S categories mildly ill or less increased from 27% at baseline to 52% at endpoint.
● The percentage of patients with PSP-defined mild functional impairment increased from 16% to 35% from baseline to endpoint.
● AEs occurring in ≥ 5% of patients were insomnia (9.2%) and anxiety (7.1%).
● ESRS scores decreased (i.e., improved) statistically significantly from 3.5 ± 5.8 to 2.1 ± 4.6 (P < 0.0001).
● Mean body weight change from baseline to endpoint was 0.3 ± 4.8 kg.
● Flexibly dosed paliperidone ER treatment over 6 months was safe, well tolerated, and associated with meaningful clinical response in patients previously unsuccessfully
treated with oral antipsychotics, supporting recent randomized controlled studies. |
| Descripción: | Póster presentado en: 27th Collegium Internationale Neuro-Psychopharmacologicum (CINP) World Congress 2010. Hong Kong: 6-10 Junio de 2010. |
| URL persistente: | http://hdl.handle.net/10401/1491 |
| Aparece en las colecciones: | Esquizofrenia y otras Psicosis
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