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http://hdl.handle.net/10401/1487
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| Título: | A flexible-dose study of Paliperidone ER in non-acute patients with schizophrenia previously unsuccessfully treated with oral Quetiapine. |
| Autor: | Tessier, C.
Hoeben, D.
Lahaye, M.
Bain-Bold, K.S.
Millet, B.
Bagalà, A.
Franco, M.
Ivanov, M.
Georgiou, G.
Schreiner, A. |
| Fecha: | jun-2010 |
| Tipo de documento: | Comunicación congreso |
| Resumen: | ● Among non-acute patients transitioned from previous oral quetiapine treatment to paliperidone ER for the main reason of
lack of efficacy, 62% of patients had an improvement in PANSS total scores of ≥ 20% from baseline to endpoint.
● Among patients switching to paliperidone ER from oral quetiapine for main reasons other than lack of efficacy, PANSS total score at endpoint was not inferior to total PANSS score at baseline.
● Numerical improvement was greatest among patients switching for the main reason of lack of compliance. However, baseline PANSS
total was also most impaired in this group and previous data has shown improvement after switching antipsychotic therapy may be
greater among patients with greater baseline impairment.
● Furthermore, PANSS total score from baseline to endpoint,showing improvement, was statistically significant (P < 0.05).
● Clinically relevant and statistically significant improvements were observed in PANSS total, subscale, and Marder factor
scores (P < 0.0001), with significant improvements in PANSS total scores noted at the first post-baseline assessment
(4 weeks after initiating paliperidone ER).
● The percentage of patients with mild functional impairment increased from 15% at baseline to 34% at endpoint.
● Flexibly dosed paliperidone ER over 6 months was safe, well tolerated, and associated with meaningful treatment response in patients previously unsuccessfully treated with oral quetiapine. |
| Descripción: | Póster presentado en: 27th Collegium Internationale Neuro-Psychopharmacologicum (CINP) World Congress 2010. Hong Kong: 6-10 Junio de 2010. |
| URL persistente: | http://hdl.handle.net/10401/1487 |
| Aparece en las colecciones: | Esquizofrenia y otras Psicosis
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