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|Título: ||Predictors for dosing, treatment response, and use of benzodiazepines in patients with acute schizophrenia.|
|Autor: ||Schreiner, A.|
|Fecha: ||jun-2010 |
|Tipo de documento: ||Comunicación congreso|
|Resumen: ||● Flexibly dosed paliperidone ER treatment for patients hospitalized with acute schizophrenia over 6 weeks was safe, well tolerated, and associated with meaningful clinical responses.
● Overall, there were some significant differences between countries which influenced dosing and clinical response.
● A higher baseline CGI-S score was a significant clinical predictor of a dose increase above 6 mg/day; a trend was also seen for higher number of previous hospitalizations.
● Significant clinical predictors of mode dose of 9 mg/day were high BMI and a higher number of hospitalizations during the
previous 12 months.
● Clinical response (defined as a decrease in PANSS total score of ≥ 30% and a decrease in CGI-S score of ≥ 1 point) occurred in 62% of patients.
– Clinical response was predicted by a residual versus paranoid schizophrenia diagnosis, early response, and country.
● High response (defined as a decrease in PANSS total score of ≥ 50% and a decrease in CGI-S score of ≥ 2 points) was observed in 23% of patients.
– High responders were more likely to have experienced an early high response, be female, and have a higher baseline CGI-S score
● 72% of patients received a concomitant BZD during the study.
– 65% received a new BZD after enrolment
– A higher baseline CGI-S score predicted concomitant use of a BZD
● Age, baseline PANSS total, and PSP scores did not predict dosing, clinical or high response, or concomitant BZD use.
● Paliperidone ER was generally well tolerated.
– Most TEAEs were mild to moderate in severity and did not result in treatment discontinuation|
|Descripción: ||Póster presentado en: 27th Collegium Internationale Neuro-Psychopharmacologicum (CINP) World Congress 2010. Hong Kong: 6-10 Junio de 2010.|
|URL persistente: ||http://hdl.handle.net/10401/1484|
|Aparece en las colecciones: ||Esquizofrenia y otras Psicosis|
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