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Esquizofrenia y otras Psicosis >
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http://hdl.handle.net/10401/1484
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| Título: | Predictors for dosing, treatment response, and use of benzodiazepines in patients with acute schizophrenia. |
| Autor: | Schreiner, A.
Tessier, C.
Blanc, M.
Bidzan, L.
Hoeben, D.
Badescu, G.M.
Niolu, C.
Jukic, V. |
| Fecha: | jun-2010 |
| Tipo de documento: | Comunicación congreso |
| Resumen: | ● Flexibly dosed paliperidone ER treatment for patients hospitalized with acute schizophrenia over 6 weeks was safe, well tolerated, and associated with meaningful clinical responses.
● Overall, there were some significant differences between countries which influenced dosing and clinical response.
● A higher baseline CGI-S score was a significant clinical predictor of a dose increase above 6 mg/day; a trend was also seen for higher number of previous hospitalizations.
● Significant clinical predictors of mode dose of 9 mg/day were high BMI and a higher number of hospitalizations during the
previous 12 months.
● Clinical response (defined as a decrease in PANSS total score of ≥ 30% and a decrease in CGI-S score of ≥ 1 point) occurred in 62% of patients.
– Clinical response was predicted by a residual versus paranoid schizophrenia diagnosis, early response, and country.
● High response (defined as a decrease in PANSS total score of ≥ 50% and a decrease in CGI-S score of ≥ 2 points) was observed in 23% of patients.
– High responders were more likely to have experienced an early high response, be female, and have a higher baseline CGI-S score
● 72% of patients received a concomitant BZD during the study.
– 65% received a new BZD after enrolment
– A higher baseline CGI-S score predicted concomitant use of a BZD
● Age, baseline PANSS total, and PSP scores did not predict dosing, clinical or high response, or concomitant BZD use.
● Paliperidone ER was generally well tolerated.
– Most TEAEs were mild to moderate in severity and did not result in treatment discontinuation |
| Descripción: | Póster presentado en: 27th Collegium Internationale Neuro-Psychopharmacologicum (CINP) World Congress 2010. Hong Kong: 6-10 Junio de 2010. |
| URL persistente: | http://hdl.handle.net/10401/1484 |
| Aparece en las colecciones: | Esquizofrenia y otras Psicosis
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